A DOUBLE-BLIND CONTROLLED COMPARISON OF GENERIC AND TRADE-NAME TOPICAL STEROIDS USING THE VASOCONSTRICTION ASSAY

被引：38

作者：

OLSEN, EA

机构：

来源：

ARCHIVES OF DERMATOLOGY | 1991年 / 127卷 / 02期

关键词：

D O I：

10.1001/archderm.127.2.197

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Six generic formulations of five topical steroids were compared for bioequivalence with their trade-name counterparts using an in vivo vasoconstriction assay. Two of six generic formulations were found to show significantly less vasoconstriction than the respective trade-name topical steroids. The issue of generic equivalence of topical steroids is discussed, with particular emphasis on the vagaries of the vasoconstriction assay.

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页码：197 / 201

页数：5

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