CONVENIENT SYNTHESES OF STEREOISOMERIC 1,2-EPOXYESTR-4-EN-3-ONES, PUTATIVE INTERMEDIATES IN ESTRADIOL METABOLISM

被引：14

作者：

MENBERU, D ^{[1
]}

NGUYEN, PV ^{[1
]}

ONAN, KD ^{[1
]}

LEQUESNE, PW ^{[1
]}

机构：

[1] NORTHEASTERN UNIV,DEPT CHEM,BOSTON,MA 02115

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 07期

关键词：

D O I：

10.1021/jo00033a035

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New synthetic sequences are described for 17-beta-hydroxy-1-beta,2-beta- and -1-alpha,2-alpha-epoxyestr-4-en-3-one, which are putative intermediates in the metabolism of estradiol to the 2,3- and 3,4-catecholestrogens, as well as the synthetic precursors of choice for these catechols.

引用

页码：2100 / 2104

页数：5

共 7 条

[1]

ABDELBAKY S, 1983, THESIS NE U BOSTON

[2] THE RISK OF BREAST-CANCER AFTER ESTROGEN AND ESTROGEN PROGESTIN REPLACEMENT [J].