ABSENCE OF GROWTH-HORMONE RECEPTOR IN HEPATOCELLULAR-CARCINOMA AND CIRRHOTIC LIVER

被引:64
作者
CHANG, TC
LIN, JJ
YU, SC
CHANG, TJ
机构
[1] NATL TAIWAN UNIV, COLL MED, DEPT INTERNAL MED, TAIPEI, TAIWAN
[2] NATL TAIWAN UNIV, COLL MED, DEPT SURG, TAIPEI, TAIWAN
[3] NATL CHUNG HSING UNIV, COLL AGR, DEPT VET MED, TAICHUNG, TAIWAN
关键词
D O I
10.1002/hep.1840110121
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatocellular carcinoma is a hormone‐sensitive tumor. It has been reported that thyroxine and prolactin significantly stimulated hepatoma growth, whereas growth hormone failed to do so. To learn whether the growth hormone receptor is present in human hepatocellular carcinoma, we used radioreceptor assays in samples of human hepatocellular carcinoma. The liver tissues adjacent to hepatocellular carcinoma (mostly cirrhotic) and control liver tissues (taken during various surgical procedures) were also studied. The study results showed that the affinity constant and capacity of high‐affinity growth hormone receptor in normal liver tissues were 6.6 ± 2.0 × 1010 mol/L−1 (mean ± SE, n = 7) and 20.7 ± 11.5 fmol/mg protein, respectively. The affinity constant and capacity of low‐affinity growth hormone receptor in normal liver tissues were 8.9 ± 3.3 × 109 mol/L−1 and 64.7 ± 32.1 fmol/mg protein, respectively. The absence of growth hormone receptor in human hepatocellular carcinoma and cirrhotic liver samples may explain the absence of growth hormone in the stimulation of hepatoma growth and the decrease of somatomedin levels in cirrhosis. (HEPATOLOGY 1990; 11: 123–126) Copyright © 1990 American Association for the Study of Liver Diseases
引用
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页码:123 / 126
页数:4
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