REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY THERMOSPRAY MASS-SPECTROMETRY OF RADIATION-INDUCED DECOMPOSITION PRODUCTS OF THYMINE AND THYMIDINE

被引：11

作者：

BERGER, M

CADET, J

BERUBE, R

LANGLOIS, R

VANLIER, JE

机构：

[1] CEN,SESM,DRFMC,LESIONS ACIDES NUCL LAB,85X,F-38041 GRENOBLE,FRANCE

[2] UNIV SHERBROOKE,FAC MED,SPECTROMETRIE MASSE LAB,SHERBROOKE J1H 5N4,QUEBEC,CANADA

[3] UNIV SHERBROOKE,FAC MED,CRM SCI RADIAT GRP,SHERBROOKE J1H 5N4,QUEBEC,CANADA

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 593卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0021-9673(92)80277-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

High-performance liquid chromatography-thermospray mass spectrometry was applied to the analysis of various radiation-induced decomposition products of thymidine including N-(2-deoxy-beta-D-erythro-pentofuranosyl)formamide and the various diastereomers of 5,6-dihydroxy-5,6-dihydrothymidine, 5-hydroxy-5,6-dihydrothymidine and 5,6-dihydrothymidine. This method combines high sensitivity and product resolution, rendering it particularly useful for monitoring the formation of radiation-induced base damage within DNA.

引用

页码：133 / 138

页数：6

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