MECHANISMS OF PENETRATION ENHANCEMENT FOR TRANSBUCCAL DELIVERY OF SALICYLIC-ACID

被引：51

作者：

GANDHI, R ^{[1
]}

ROBINSON, J ^{[1
]}

机构：

[1] UNIV WISCONSIN, SCH PHARM, MADISON, WI 53706 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 85卷 / 1-3期

关键词：

PENETRATION ENHANCER; SALICYLIC ACID; BUCCAL DELIVERY; SODIUM DEOXYCHOLATE; SODIUM LAURYL SULFATE; ELECTRICAL RESISTANCE; PROTEIN TRANSITION; LIPID TRANSITION;

D O I：

10.1016/0378-5173(92)90142-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The process of in vitro permeation across rabbit buccal mucosa was examined using salicylic acid as a model compound. The promoting action of penetration enhancers on salicylic acid flux was studied using differential scanning calorimetry, flux, electrophysiology, and microscopy techniques. The enhancers, sodium deoxycholate and sodium lauryl sulfate, decrease the electrical resistance and increase the permeability of salicylic acid across rabbit buccal mucosa. The results of these techniques appear to support the premise that the superficial layers and protein domain of the epithelium may be responsible for maintaining the barrier function of the buccal mucosa. This work provides additional insight in identification of the permeability barrier and the mechanism of enhancer activity.

引用

页码：129 / 140

页数：12

共 18 条

[1] PHASE-TRANSITIONS AND FLUIDITY CHARACTERISTICS OF LIPIDS AND CELL-MEMBRANES [J].