INTERFERON-GAMMA AND TUMOR-NECROSIS-FACTOR PRODUCTION IN PATIENTS WITH HELICOBACTER-PYLORI INFECTION

被引：30

作者：

FAN, XJ ^{[1
]}

CHUA, A ^{[1
]}

OCONNELL, MA ^{[1
]}

KELLEHER, D ^{[1
]}

KEELING, PWN ^{[1
]}

机构：

[1] TRINITY COLL DUBLIN,ST JAMES HOSP,SCH MED,DEPT CLIN MED,DUBLIN 8,IRELAND

来源：

IRISH JOURNAL OF MEDICAL SCIENCE | 1993年 / 162卷 / 10期

关键词：

D O I：

10.1007/BF02996319

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The production of the cytokines, interferon-gamma and tumour necrosis factor by human antral mucosa cells and stimulated peripheral blood mononuclear cells were determined by enzyme linked immunosorbant assay and L929 bioassay respectively. Tumour necrosis factor production by peripheral blood mononuclear cells in response to Helicobacter pylori stimulation was depressed in Helicobacter pylori positive individuals, compared to Helicobacter pylori negative individuals (P < 0.05). There was no difference in tumour necrosis factor production by peripheral blood mononuclear cells in response to purified protein derivative. However, tumour necrosis factor production by cells isolated from gastric mucosa during short term culture was significantly higher in Helicobacter pylori positive patients (P < 0.05) than negative patients, indicating a probable macrophage response. Levels of interferon-gamma did not differ significantly in the gastric explant culture from the two groups. The results show that Helicobacter pylori negative patients have a stronger peripheral cellular immune response to Helicobacter pylori infection. The higher levels of tumour necrosis factor production by antral mucosa cells in Helicobacter pylori positive patients may reflect the infiltration of T lymphocytes and macrophages within the local mucosa.

引用

页码：408 / 411

页数：4

共 32 条

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