DOPAMINE D-1 RECEPTOR FAMILY AGONISTS, SKANDF38393, SKANDF77434, AND SKANDF82958, DIFFERENTIALLY AFFECT LOCOMOTOR ACTIVITIES IN RATS

Dopamine D-1 receptor family agonists, 2,3,4,5,-tetrahydro-7,8-dihydroxy- 1phenyl-1H-3-benzazepine (SKandF38393), 3-allyl-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKandF77434), and 3-allyl-6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SK&F82958), were compared for their behavioral effects on horizontal movement time, rearing time, stereotypy time, and thigmotaxis time. All agonists resulted in biphasic effects with attenuation followed by potentiation (0.01-10.0 mg/kg, SC). While SKandF38393 did not potentiate horizontal movement and rearing times, and had minor effects on thigmotaxis, SKandF77434 and SKandF82958 potentiated horizontal movement and rearing behaviors and attenuated thigmotaxis. The results were discussed in terms of the binding characteristics and current receptor theory.