NITRIC-OXIDE MODULATES CA2+ CHANNEL CURRENTS IN RAT SYMPATHETIC NEURONS

被引：48

作者：

CHEN, C ^{[1
]}

SCHOFIELD, GG ^{[1
]}

机构：

[1] TULANE UNIV,SCH MED,DEPT PHYSIOL,1430 TULANE AVE,NEW ORLEANS,LA 70112

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 243卷 / 01期

关键词：

SYMPATHETIC GANGLION; CA2+ CHANNELS; NITRIC OXIDE (NO); NOREPINEPHRINE; VOLTAGE-CLAMP; PATCH-CLAMP;

D O I：

10.1016/0014-2999(93)90171-D

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of nitric oxide on the Ca2+ channel currents of adult rat superior cervical ganglion neurons were investigated using the whole-cell patch-clamp technique. Nitric oxide-containing compounds sodium nitroprusside and S-nitroso-N-acetylpenicillamine increased the amplitude of Ca2+ currents by intracellular application. In addition, both sodium nitroprusside and S-nitroso-N-acetylpenicillamine reduced norepinephrine-induced inhibition of Ca2+ currents. The results suggest that nitric oxide might be involved in the modulation of Ca2+-dependent neurotransmission in sympathetic neurons.

引用

页码：83 / 86

页数：4

共 15 条

[1] POTENTIATION OF NICOTINIC TRANSMISSION IN THE RAT SUPERIOR CERVICAL SYMPATHETIC-GANGLION - EFFECTS OF CYCLIC-GMP AND NITRIC-OXIDE GENERATORS
BRIGGS, CA
[J]. BRAIN RESEARCH, 1992, 573 (01) : 139 - 146
[2] CHEN C, 1993, IN PRESS J NEUROPHYS
[3] ENDOTHELIUM INHIBITS NOREPINEPHRINE RELEASE FROM ADRENERGIC-NERVES OF RABBIT CAROTID-ARTERY
COHEN, RA
WEISBROD, RM
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (05): : H871 - H878
[4] RELEASE OF NOREPINEPHRINE FROM ADRENERGIC-NERVE ENDINGS OF BLOOD-VESSELS IS MODULATED BY ENDOTHELIUM-DERIVED RELAXING FACTOR
GREENBERG, SS
DIECKE, FPJ
PEEVY, K
TANAKA, TP
[J]. AMERICAN JOURNAL OF HYPERTENSION, 1990, 3 (03) : 211 - 218
[5] HALBRUGGE T, 1991, N-S ARCH PHARMACOL, V344, P720
[6] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES
HAMILL, OP
MARTY, A
NEHER, E
SAKMANN, B
SIGWORTH, FJ
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02): : 85 - 100
[7] GTP-BINDING PROTEINS MEDIATE TRANSMITTER INHIBITION OF VOLTAGE-DEPENDENT CALCIUM CHANNELS
HOLZ, GG
RANE, SG
DUNLAP, K
[J]. NATURE, 1986, 319 (6055) : 670 - 672
[8] NITRIC-OXIDE - A NOVEL SIGNAL TRANSDUCTION MECHANISM FOR TRANSCELLULAR COMMUNICATION
IGNARRO, LJ
[J]. HYPERTENSION, 1990, 16 (05) : 477 - 483
[9] ENDOTHELIUM-DERIVED RELAXING FACTOR PRODUCED AND RELEASED FROM ARTERY AND VEIN IS NITRIC-OXIDE
IGNARRO, LJ
BUGA, GM
WOOD, KS
BYRNS, RE
CHAUDHURI, G
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (24) : 9265 - 9269
[10] NITRIC-OXIDE TAKES CENTER-STAGE WITH NEWLY DEFINED ROLES
MCCALL, T
VALLANCE, P
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (01) : 1 - 6

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