A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID

被引：51

作者：

BALDWIN, JE

LLOYD, MD

WHASON, B

SCHOFIELD, CJ

ELSON, SW

BAGGALEY, KH

NICHOLSON, NH

机构：

[1] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 06期

关键词：

D O I：

10.1039/c39930000500

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incubation of (2S)-5-amino-(2'-oxoazetidin-1'-yl)pentanoic acid with clavaminic acid synthase gave (2S)-5-amino-2-(2'-oxoazetidin-1'-yl)pent-3,4-enoic acid as the major product, together with a small amount of proclavaminic acid; modification of the amino group to the guanyl group biased the mode of reactivity from desaturation to hydroxylation.

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页码：500 / 502

页数：3

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