1.9-ANGSTROM RESOLUTION REFINED STRUCTURE OF TBP RECOGNIZING THE MINOR-GROOVE OF TATAAAAG

被引：210

作者：

KIM, JL ^{[1
]}

BURLEY, SK ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,HOWARD HUGHES MED INST,MOLEC BIOPHYS LABS,NEW YORK,NY 10021

来源：

NATURE STRUCTURAL BIOLOGY | 1994年 / 1卷 / 09期

关键词：

D O I：

10.1038/nsb0994-638

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The three-dimensional structure of a TATA box-binding protein (TBP) from Arabidopsis thaliana complexed with a fourteen base pair oligonucleotide bearing the Adenovirus major late promoter TATA element has been refined at 1.9 Angstrom resolution, giving a final crystallographic R-factor of 19.4%. Binding of the monomeric, saddle-shaped alpha/beta protein induces an unprecedented conformational change in the DNA. A detailed structural and functional analysis of this unusual protein-DNA complex is presented, with particular emphasis on the mechanisms of DNA deformation, TATA element recognition, and preinitiation complex assembly.

引用

页码：638 / 653

页数：16

共 76 条

[1] RECOGNITION OF A DNA OPERATOR BY THE REPRESSOR OF PHAGE-434 - A VIEW AT HIGH-RESOLUTION [J].

AGGARWAL, AK ;

RODGERS, DW ;

DROTTAR, M ;

PTASHNE, M ;

HARRISON, SC .

SCIENCE, 1988, 242 (4880) :899-907

[2] FREE R-VALUE - A NOVEL STATISTICAL QUANTITY FOR ASSESSING THE ACCURACY OF CRYSTAL-STRUCTURES [J].

BRUNGER, AT .

NATURE, 1992, 355 (6359) :472-475

[3]

BRUNGER AT, 1992, XPLOR MANUAL

[4]

BURATOWSKI S, 1992, SCIENCE, V255, P1030

[5] DNA-BINDING MOTIFS FROM EUKARYOTIC TRANSCRIPTION FACTORS [J].

BURLEY, SK .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1994, 4 (01) :3-11

[6] CRYSTAL-STRUCTURE OF YEAST TATA-BINDING PROTEIN AND MODEL FOR INTERACTION WITH DNA [J].

CHASMAN, DI ;

FLAHERTY, KM ;

SHARP, PA ;

KORNBERG, RD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :8174-8178

[7] BINDING OF 2 DISTAMYCIN-A MOLECULES IN THE MINOR-GROOVE OF AN ALTERNATING B-DNA DUPLEX [J].

CHEN, X ;

RAMAKRISHNAN, B ;

RAO, ST ;

SUNDARALINGAM, M .

NATURE STRUCTURAL BIOLOGY, 1994, 1 (03) :169-175

[8] EFFECTS OF MINOR-GROOVE BINDING-DRUGS ON THE INTERACTION OF TATA BOX-BINDING PROTEIN AND TFIIA WITH DNA [J].

CHIANG, SY ;

WELCH, J ;

RAUSCHER, FJ ;

BEERMAN, TA .

BIOCHEMISTRY, 1994, 33 (23) :7033-7040

[9] MOLECULAR-STRUCTURE OF THE NETROPSIN-D(CGCGATATCGCG) COMPLEX - DNA CONFORMATION IN AN ALTERNATING AT SEGMENT [J].

COLL, M ;

AYMAMI, J ;

VANDERMAREL, GA ;

VANBOOM, JH ;

RICH, A ;

WANG, AHJ .

BIOCHEMISTRY, 1989, 28 (01) :310-320

[10] ARCHITECTURAL ELEMENTS IN NUCLEOPROTEIN COMPLEXES [J].

CROTHERS, DM .

CURRENT BIOLOGY, 1993, 3 (10) :675-676

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