PI-3-KINASE INHIBITOR WORTMANNIN BLOCKS THE INSULIN-LIKE EFFECTS OF GROWTH-HORMONE IN ISOLATED RAT ADIPOCYTES

被引：53

作者：

RIDDERSTRALE, M ^{[1
]}

TORNQVIST, H ^{[1
]}

机构：

[1] LUND UNIV,DEPT MED & PHYSIOL CHEM,LUND,SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.2182

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of wortmannin, a selective phosphatidylinositol S-kinase inhibitor, on the insulin-like effects of growth hormone in isolated adipocytes from rat was investigated. Wortmannin inhibited both the lipogenic and the antilipolytic effects (IC50 approximate to 20 nM) with no effect on [I-125]-growth hormone binding to the adipocytes. These data suggest that phosphatidylinositol 3-kinase might play an important role in the insulin-like actions of growth hormone. (C) 1994 Academic Press, Inc.

引用

页码：306 / 310

页数：5

共 26 条

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