THIAZINOTRIENOMYCINS, NEW ANSAMYCIN GROUP ANTIBIOTICS

被引：36

作者：

HOSOKAWA, N ^{[1
]}

NAGANAWA, H ^{[1
]}

IINUMA, H ^{[1
]}

HAMADA, M ^{[1
]}

TAKEUCHI, T ^{[1
]}

KANBE, T ^{[1
]}

HORI, M ^{[1
]}

机构：

[1] SHOWA COLL PHARMACEUT SCI,MACHIDA,TOKYO 194,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 06期

关键词：

D O I：

10.7164/antibiotics.48.471

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New triene-ansamycins designated thiazinotrienomycins A, B, C, D and E were isolated from culture broth of Streptomyces sp. MJ672-m3 for their activities against cervical cancer cell lines. The structures and some biological and biochemical properties of the antibiotics were determined.

引用

收藏

页码：471 / 478

页数：8

相关论文

共 9 条

[1] 2 NOVEL PHENOLICS FROM ACTINOMADURA-VERRUCOSOSPORA [J].

BEUTLER, JA ;

CHMURNY, GN ;

CLARK, P ;

METRAL, CJ ;

ROMAN, J ;

FORENZA, S .

JOURNAL OF ANTIBIOTICS, 1990, 43 (01) :107-109

[2] STRUCTURES OF TRIENOMYCINS A, B AND C, NOVEL CYTOCIDAL ANSAMYCIN ANTIBIOTICS [J].

FUNAYAMA, S ;

OKADA, K ;

IWASAKI, K ;

KOMIYAMA, K ;

UMEZAWA, I .

JOURNAL OF ANTIBIOTICS, 1985, 38 (12) :1677-1683

[3]

HORI Y, 1994, Patent No. 239749

[4] STRUCTURAL STUDIES ON MINOR COMPONENTS OF TRIENOMYCIN GROUP ANTIBIOTICS TRIENOMYCIN-D AND TRIENOMYCIN-E [J].

NOMOTO, H ;

KATSUMATA, S ;

TAKAHASHI, K ;

FUNAYAMA, S ;

KOMIYAMA, K ;

UMEZAWA, I ;

OMURA, S .

JOURNAL OF ANTIBIOTICS, 1989, 42 (03) :479-481

[5] BIOSYNTHESIS OF ANSATRIENIN BY STREPTOMYCES-COLLINUS - CELL-FREE TRANSFORMATIONS OF CYCLOHEXENECARBOXYLIC AND CYCLOHEXADIENECARBOXYLIC ACIDS [J].

REYNOLDS, KA ;

WANG, P ;

FOX, KM ;

FLOSS, HG .

JOURNAL OF ANTIBIOTICS, 1992, 45 (03) :411-419

[6] STUDIES ON MYCOTRIENIN ANTIBIOTICS, A NOVEL CLASS OF ANSAMYCINS .1. TAXONOMY, FERMENTATION, ISOLATION AND PROPERTIES OF MYCOTRIENIN-I AND MYCOTRIENIN-II [J].

SUGITA, M ;

NATORI, Y ;

SASAKI, T ;

FURIHATA, K ;

SHIMAZU, A ;

SETO, H ;

OTAKE, N .

JOURNAL OF ANTIBIOTICS, 1982, 35 (11) :1460-1466

[7] SCREENING OF ANTIBIOTICS PREFERENTIALLY ACTIVE AGAINST RAS ONCOGENE-EXPRESSED CELLS [J].

SUZUKAKETSUCHIYA, K ;

MORIYA, Y ;

YAMAZAKI, K ;

HORI, M ;

HOSOKAWA, N ;

SAWA, T ;

IINUMA, H ;

NAGANAWA, H ;

IMADA, C ;

HAMADA, M .

JOURNAL OF ANTIBIOTICS, 1990, 43 (11) :1489-1496

[8] 2 SULFUR-CONTAINING ANSAMYCIN ANTIBIOTICS FROM STREPTOMYCES-ALBOLONGUS [J].

TANIDA, S ;

SHINAGWA, S ;

TAKIZAWA, M ;

TAKAHASHI, T ;

HARADA, S ;

HASEGAWA, T .

EXPERIENTIA, 1986, 42 (10) :1167-1170

[9] BIOSYNTHESIS OF THE ANSAMYCIN ANTIBIOTIC ANSATRIENIN (MYCOTRIENIN) BY STREPTOMYCES-COLLINUS [J].

WU, TS ;

DUNCAN, J ;

TSAO, SW ;

CHANG, CJ ;

KELLER, PJ ;

FLOSS, HG .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (01) :108-118