Although the diagnosis of pulmonary tuberculosis is not possible with radionuclide imaging alone, and in spite of the fact that the lung scan does not allow a classification of pulmonary tuberculosis into its various clinical and anatomical-pathological forms, it has its place in the work-up of this disease. Radionuclide imaging demonstrates precise delineation of regional lung function (ventilation and perfusion), which is particularly important in the prognosis of patients with specific problems: those in whom there is a long delay in the conversion from positive to negative sputum; those in whom the sputum remains positive in spite of adequate therapy; those in whom specific lesions resolve very slowly or not at all. In addition, these studies are useful in the preoperative work-up of patients with therapy resistant lesions.