HISTO-PATHOLOGY OF SKIN, LIVER, AND KIDNEY AFTER EPICUTANEOUS ADMINISTRATION OF 5 INDUSTRIAL SOLVENTS TO GUINEA-PIGS

The histopathology of the skin, liver, and kidney was studied in guinea pigs after epicutaneous administration of the industrial solvents n-hexane, toluene, carbon tetrachloride, 2-chloroethanol, and n-butyl acetate. Exposure to hexane, toluene, carbon tetrachloride, and 2-chloroethanol caused progressing nuclear pyknosis and junctional separation between the basement membrane and the basal cells. Toluene and carbon tetrachloride did also induce spongiosis appearing before the junctional separation. n-Butyl acetate did not induce any skin lesion. The liver morphology was characterized by hydropic and necrotic changes for carbon tetrachloride and 2-chloroethanol but no changes were observed for the other solvents. The kidney morphology was normal for all exposed animals. © 1979.