ASPYRONE BIOSYNTHESIS IN ASPERGILLUS-MELLEUS - IDENTIFICATION OF THE INTERMEDIATES FORMED ON THE POLYKETIDE SYNTHASE (PKS) IN THE 1ST CHAIN EXTENSION CYCLE LEADING TO CROTONATE

被引：26

作者：

JACOBS, A ^{[1
]}

STAUNTON, J ^{[1
]}

SUTKOWSKI, AC ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,CHEM LAB,LENSFIELD RD,CAMBRIDGE CB2 1EW,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 16期

关键词：

D O I：

10.1039/c39910001113

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incorporation studies, using intact cells of Aspergillus melleus and deuterium labelled precursors in association with H-2 NMR spectroscopy as method of analysis, have shown that the enzyme-bound intermediates generated in the first two steps of the chain extension cycle catalysed by the aspyrone polyketide synthase (PKS) are thioesters of acetoacetic acid and (R)-3-hydroxybutyric acid.

引用

页码：1113 / 1114

页数：2

共 8 条

[1] MACROLIDE BIOSYNTHESIS .4. INTACT INCORPORATION OF A CHAIN-ELONGATION INTERMEDIATE INTO ERYTHROMYCIN
CANE, DE
YANG, CC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (04) : 1255 - 1257
[2] BIOSYNTHESIS OF 6-METHYLSALICYLIC ACID
DIMROTH, P
WALTER, H
LYNEN, F
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1970, 13 (01): : 98 - &
[3] NUMA S, 1984, FATTY ACID METABOLIS, P29
[4] SCOTT AI, 1974, BIOORG CHEM, V3, P2387
[5] NONACTIN BIOSYNTHESIS - ON THE ROLE OF (6R,8R)-2-METHYL-6,8-DIHYDROXYNON-2E-ENOIC AND (6S,8S)-2-METHYL-6,8-DIHYDROXYNON-2E-ENOIC ACIDS IN THE FORMATION OF NONACTIC ACID
SPAVOLD, ZM
ROBINSON, JA
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (01) : 4 - 6
[6] STAUNTON J, 1991, J CHEM SOC CHEM COMM
[7] INTACT INCORPORATION OF ACETATE-DERIVED DIKETIDES AND TETRAKETIDES DURING BIOSYNTHESIS OF DEHYDROCURVULARIN, A MACROLIDE PHYTOTOXIN FROM ALTERNARIA-CINERARIAE
YOSHIZAWA, Y
LI, Z
REESE, PB
VEDERAS, JC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (08) : 3212 - 3213
[8] MACROLIDE BIOSYNTHESIS - TYLACTONE FORMATION INVOLVES THE PROCESSIVE ADDITION OF 3 CARBON UNITS
YUE, S
DUNCAN, JS
YAMAMOTO, Y
HUTCHINSON, CR
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (04) : 1253 - 1255

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