THE MUTAGENICITY OF AZIDO DERIVATIVES OF MONOSACCHARIDES AND ALCOHOLS AND OF N-(3-AZIDO-2-HYDROXYPROPYL) DERIVATIVES OF PURINES AND PYRIMIDINES IN ARABIDOPSIS-THALIANA AND IN SALMONELLA-TYPHIMURIUM

被引：7

作者：

GICHNER, T ^{[1
]}

HOLY, A ^{[1
]}

SPASSOVA, M ^{[1
]}

VELEMINSKY, J ^{[1
]}

GRUZ, P ^{[1
]}

机构：

[1] INST ORGAN CHEM & BIOCHEM, CS-16000 PRAGUE 6, CZECHOSLOVAKIA

来源：

MUTAGENESIS | 1991年 / 6卷 / 01期

关键词：

SODIUM-AZIDE; METABOLITE; AZIDOALANINE;

D O I：

10.1093/mutage/6.1.55

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The azido derivatives of alcohols (3-azido-1,2-propandiol and 1,3-diazido-2-propanol) and monosaccharides (6-azido-6-deoxy-beta-D-glucose and 6-azido-6-deoxy-beta-D-galactose), as well as the proximal mutagenic product of sodium azide metabolism beta-azido-L-alanine, exhibited a high mutagenic activity in a higher plant Arabidopsis thaliana and in Salmonella typhimurium. In contrast, 11 N-(3-azido-2-hydroxypropyl) derivatives of purines and pyrimidines (adenine, thymine, uracil, cytosine, 2-amino-6-chloropurine, 6-chloropurine, 2,6-diaminopurine, 6-methylthiopurine, 4-O-methylthymine, 4-O-methyluracil and 7-deaza-8-azaadenine) were mutagenic in the Ames assay but ineffective in the Arabidopsis mutagenicity assay.

引用

页码：55 / 58

页数：4

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