SYNTHESIS AND ANTIRHINOVIRUS ACTIVITY OF CYANO AND AMIDINO SUBSTITUTED FLAVANOIDS

被引：22

作者：

CONTI, C ^{[1
]}

DESIDERI, N ^{[1
]}

ORSI, N ^{[1
]}

SESTILI, I ^{[1
]}

STEIN, ML ^{[1
]}

机构：

[1] UNIV LA SAPIENZA,DIPARTIMENTO STUDI FARMACEUT,I-00185 ROME,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 25卷 / 09期

关键词：

SUBSTITUTED FLAVANS; SUBSTITUTED ISOFLAVANS; SUBSTITUTED ISOFLAVENES; RHINOVIRUS;

D O I：

10.1016/0223-5234(90)90191-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cyano and amidino flavans, isoflavans and 3(2H)-isoflavenes were synthesized in order to study their in vitro antirhinovirus activity, by comparison with the known corresponding chloro derivatives. The activity of the new compounds was evaluated on rhinovirus 1 B infected HeLa cell cultures by examining their ability to interfere with viral cytopathic effect and with plaque formation. It was found that generally the cyano derivatives behave like the chloro compounds, whereas the amidino derivatives show a lower activity, although always dependent on the position of substituent.

引用

页码：725 / 730

页数：6

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