GENERATION OF A SUBTYPE-SPECIFIC NEUTRALIZATION EPITOPE IN FOOT-AND-MOUTH-DISEASE VIRUS OF A DIFFERENT SUBTYPE

被引：21

作者：

HERNANDEZ, J ^{[1
]}

MARTINEZ, MA ^{[1
]}

ROCHA, E ^{[1
]}

DOMINGO, E ^{[1
]}

MATEU, MG ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID,CTR BIOL MOLEC,CANTO BLANCO,E-28049 MADRID,SPAIN

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-1-213

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An epitope involved in neutralization of foot-and-mouth disease virus (FMDV) of subtype C3 was generated by a single amino acid replacement in VP1 of FMDV of subtype C1. The replacement [Ser (139) --> Ile, in the immunodominant site A] was consistently found in those FMDV C1 Santa Pau-Sp/70 mutants resistant to neutralization by monoclonal antibody (MAb) SD6 (specific for most C1 viruses) that acquired the capacity to be neutralized by MAb 7AB5 (specific for C3 viruses).

引用

页码：213 / 216

页数：4

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