CHEMOTACTIC CYTOKINE (IL-8 AND MCP-1) GENE-EXPRESSION BY HUMAN WHOLE-BLOOD

被引：17

作者：

HAM, JM

KUNKEL, SL

DIBB, CR

STANDIFORD, TJ

ROLFE, MW

STRIETER, RM

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,SCH MED,DEPT SURG,ANN ARBOR,MI 48109

来源：

IMMUNOLOGICAL INVESTIGATIONS | 1991年 / 20卷 / 04期

关键词：

D O I：

10.3109/08820139109057764

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The salient features of systemic or local inflammation are the myriad of cellular and humoral interactions that result in elicitation of inflammatory leukocytes. In this study using specialized connective tissue, intact whole blood, we demonstrate the gene expression of two novel chemotactic factors. The buffy-coat cellular expression of neutrophil chemotactic/activating factor/interleukin 8 (IL-8) and monocyte chemotactic/activating protein (MCP-1) mRNA were time and dose-dependent in response to either lipopolysaccharide or zymosan stimulation. This system with the complexity of tissue provides a unique model for the determination of chemotactic cytokine gene expression.

引用

页码：387 / 394

页数：8

共 9 条

[1] NEUTROPHIL-ACTIVATING PEPTIDE-1 INTERLEUKIN-8, A NOVEL CYTOKINE THAT ACTIVATES NEUTROPHILS [J].