MOLECULAR SELF-DIFFUSION OF INTRACELLULAR METABOLITES IN RAT-BRAIN INVIVO INVESTIGATED BY LOCALIZED PROTON NMR DIFFUSION SPECTROSCOPY

被引：63

作者：

MERBOLDT, KD ^{[1
]}

HORSTERMANN, D ^{[1
]}

HANICKE, W ^{[1
]}

BRUHN, H ^{[1
]}

FRAHM, J ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,NMR POSTFACH 2841,W-3400 GOTTINGEN,GERMANY

来源：

MAGNETIC RESONANCE IN MEDICINE | 1993年 / 29卷 / 01期

关键词：

RAT; BRAIN; METABOLITES; PROTON; SPECTROSCOPY; DIFFUSION;

D O I：

10.1002/mrm.1910290123

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Molecular self-diffusion coefficients of water (0.75 +/- 0.05), N-acetylaspartate (0.27 +/- 0.04), creatines (0.27 +/- 0.04), and cholines (0.28 +/- 0.08) x 10(-5) cm2 S-1 were obtained from localized proton NMR spectra of rat brain in vivo using diffusion-weighted stimulated-echo (STEAM) sequences with a diffusion time of (DELTA - delta/3) = 17 ms.

引用

页码：125 / 129

页数：5

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