EFFECT OF HALOTHANE ON CILIA BEAT FREQUENCY OF CILIATED HUMAN RESPIRATORY EPITHELIUM IN-VITRO

被引：21

作者：

GYI, A ^{[1
]}

OCALLAGHAN, C ^{[1
]}

LANGTON, JA ^{[1
]}

机构：

[1] UNIV LEICESTER,LEICESTER ROYAL INFIRM,DEPT CHILD HLTH,LEICESTER LE1 5WW,LEICS,ENGLAND

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1994年 / 73卷 / 04期

关键词：

ANESTHETICS VOLATILE; HALOTHANE; LUNG; CILIA;

D O I：

10.1093/bja/73.4.507

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The effect of halothane on human ciliated nasal epithelium was studied in vitro. Samples from 24 healthy adult volunteers were exposed to halothane in varying concentrations and cilia beat frequency was measured using the transmitted light technique. Mean cilia beat frequency was measured at 30-min intervals. There was a significant decrease in cilia beat frequency at 2 h in samples that were exposed to halothane (mean 8.4 (SD 2.5) Hz, 9.18 (2.6) Hz and 6.99 (4.9) Hz) compared with air (10.8 (2.7) Hz, 11.6(2.1) Hz and 12.1(2.3) Hz) (P < 0.01). The coefficient of variation of cilia beat frequency measurements increased after exposure to halothane. There was no change in the cilia beat frequency of controls exposed to air over a 3-h period.

引用

页码：507 / 510

页数：4

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