PHOSPHONOMYCIN, A NEW ANTIBIOTIC PRODUCED BY STRAINS OF STREPTOMYCES

被引：539

作者：

HENDLIN, D

STAPLEY, EO

JACKSON, M

WALLICK, H

MILLER, AK

WOLF, FJ

MILLER, TW

CHAIET, L

KAHAN, FM

FOLTZ, EL

WOODRUFF, HB

机构：

[1] Merck Institute for Therapeutic, Research-Merck Sharp and Dohme Research Laboratories, Rahway, NJ

[2] Compañía Española de la Penicilina y Antibioticos, Madrid

来源：

SCIENCE | 1969年 / 166卷 / 3901期

关键词：

D O I：

10.1126/science.166.3901.122

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phosphonomycin is a newly discovered antibiotic produced by streptomycetes. It is effective, when administered by the oral route, to mice infected with Gram-positive or Gram-negative microorganisms. The antibiotic is bactericidal and inhibits cell-wall synthesis.

引用

页码：122 / &

共 10 条

[1] CHAIET L, IN PREPARATION
[2] PHOSPHONOMYCIN - STRUCTURE AND SYNTHESIS
CHRISTENSEN, BG
LEANZA, WJ
BEATTIE, TR
PATCHETT, AA
ARISON, BH
ORMOND, RE
KUEHL, FA
ALBERSSC.G
JARDETZKY, O
[J]. SCIENCE, 1969, 166 (3901) : 123 - +
[3] FOLTZ EL, IN PREPARATION
[4] GUNETILEKE KG, 1968, J BIOL CHEM, V243, P5770
[5] KAHAN FM, IN PREPARATION
[6] KOCH JP, 1964, J BIOL CHEM, V239, P3106
[7] ANTIBACTERIAL CHEMOTHERAPY TESTS - INFLUENCE OF CHALLENGE PREPARATION + OF DOSAGE SCHEDULE ON IN VIVO EFFECTIVENESS OF BACTERIOSTATIC + BACTERICIDAL ANTIBIOTIC
MILLER, AK
[J]. CHEMOTHERAPY, 1964, 8 (03) : 154 - +
[8] CROSS-RESISTANCE STUDIES AND ANTIBIOTIC IDENTIFICATION
STAPLEY, EO
[J]. APPLIED MICROBIOLOGY, 1958, 6 (06) : 392 - 398
[9] ENZYMIC TRANSFER OF PYRUVATE TO URIDINE DIPHOSPHOACETYLGLUCOSAMINE
STROMINGER, JL
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1958, 30 (03) : 645 - 646
[10] Vincent JG, 1944, P SOC EXP BIOL MED, V55, P162, DOI 10.3181/00379727-55-14502

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