DIRECT INTERACTION OF LSD WITH CENTRAL BETA-ADRENERGIC RECEPTORS

被引:11
作者
DOLPHIN, A [1 ]
ENJALBERT, A [1 ]
TASSIN, JP [1 ]
LUCAS, M [1 ]
BOCKAERT, J [1 ]
机构
[1] COLL FRANCE,NB GRP U114,F-75231 PARIS 5,FRANCE
关键词
D O I
10.1016/0024-3205(78)90142-X
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
(+)-lysergic acid diethylamide (LSD) has been found to interact with central β-adrenergic receptors, both in the cerebral cortex of the rat and in cultured C 6 glioma cells. LSD inhibited the binding of 3H-dihydroalprenolol (3H-DHA) with an apparent inhibition constant of 10-7M in the cerebral cortex and 10-6M in C 6 glioma cells. The displacement of 3H-DHA binding by LSD was found to be competitive in the cortex, with a dissociation constant of 1.9 × 10-7M, compared to 1.4 × 10-8M for (-) alprenolol and 5.6 × 10-8M for (-) isoproterenol. BOL, an analogue of LSD without hallucinogenic properties, showed the same affinity as LSD for the cortical β-adrenergic receptor. However, several dopamine and serotonin agonists and antagonists were without effect at 10-6M. The stimulation of adenylate cyclase by isoproterenol was inhibited by LSD with an apparent inhibition constant of 1.6 × 10-7M in homogenates of cerebral cortex and 5 × 10-6M in the C 6 glioma cell system. The results suggest that central β-adrenergic receptors represent one of the several sites of action of LSD. © 1978.
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页码:345 / 351
页数:7
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