PROTECTION OF MICE AGAINST THE LYME-DISEASE AGENT BY IMMUNIZING WITH RECOMBINANT OSPA

被引：451

作者：

FIKRIG, E

BARTHOLD, SW

KANTOR, FS

FLAVELL, RA

机构：

[1] YALE UNIV, SCH MED, DEPT INTERNAL MED, DIV INFECT DIS, NEW HAVEN, CT 06510 USA

[2] YALE UNIV, SCH MED, COMPARAT MED SECT, NEW HAVEN, CT 06510 USA

[3] YALE UNIV, SCH MED, DEPT INTERNAL MED, DIV ALLERGY & CLIN IMMUNOL, NEW HAVEN, CT 06510 USA

[4] YALE UNIV, SCH MED, IMMUNOBIOL SECT, NEW HAVEN, CT 06510 USA

[5] YALE UNIV, SCH MED, HOWARD HUGHES MED INST, NEW HAVEN, CT 06510 USA

来源：

SCIENCE | 1990年 / 250卷 / 4980期

关键词：

D O I：

10.1126/science.2237407

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lyme borreliosis is a tick-borne illness caused by Borrelia burgdorferi. The gene for outer surface protein A (OspA) from B. burgdorferi strain N40 was cloned into an expression vector and expressed in Escherichia coli. C3H/HeJ mice actively immunized with live transformed E. coli or purified recombinant OspA protein produced antibodies to OspA and were protected from challenge with several strains of B. burgdorferi. Recombinant OspA is a candidate for a vaccine for Lyme borreliosis.

引用

页码：553 / 556

页数：4

共 20 条

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