DOPAMINERGIC GRAFTS IN THE STRIATUM REDUCE D1 BUT NOT D2 RECEPTOR-MEDIATED ROTATION IN 6-OHDA-LESIONED RATS

被引：29

作者：

ROBERTSON, GS

FINE, A

ROBERTSON, HA

机构：

[1] DALHOUSIE UNIV,FAC MED,DEPT PHARMACOL,HALIFAX B3H 4H7,NS,CANADA

[2] DALHOUSIE UNIV,FAC MED,DEPT PHYSIOL & BIOPHYS,HALIFAX B3H 4H7,NS,CANADA

来源：

BRAIN RESEARCH | 1991年 / 539卷 / 02期

关键词：

NEURAL TRANSPLANTATION; D1; RECEPTOR; D2; ROTATION; STRIATUM; SUBSTANTIA NIGRA;

D O I：

10.1016/0006-8993(91)91634-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats received fetal dopaminergic neuronal grafts in the striatum and/or substantia nigra ipsilateral to a 6-hydroxydopamine (6-OHDA) lesion of the medial forebrain bundle (MFB). Dopaminergic grafts in the striatum substantially and significantly reduced turning elicited by the selective D1 agonist SKF 38393, but did not reduce turning elicited by the selective D2 agonist LY 171555. Thus, reduced turning in such grafted animals in response to non-selective dopaminergic agonists may be the result of diminished D1 supersensitivity. Fetal dopaminergic grafts in the ipsilateral substantia nigra (SN) did not augment the decreases in turning produced by concomitant ipsilateral dopaminergic grafts in the striatum in response to SKF 38393, LY 171555, D-amphetamine or L-DOPA. Dopaminergic grafts in the SN increased, while dopaminergic grafts in the striatum or in striatum and SN decreased, the facilitatory effect of D-amphetamine on rotation elicited by subsequent injection of dopamine agonists.

引用

页码：304 / 311

页数：8

共 33 条

[1] DIFFERENTIAL INHIBITION BY DOPAMINE D-1 AND D-2 ANTAGONISTS OF CIRCLING BEHAVIOR INDUCED BY DOPAMINE AGONISTS IN RATS WITH UNILATERAL 6-HYDROXYDOPAMINE LESIONS [J].