INHIBITION OF RAT HEPATIC-MICROSOMAL CYTOCHROME-P-450 SYSTEM BY COBALTOUS CHLORIDE AND REVERSAL OF INHIBITION BY IRON INVIVO

被引：5

作者：

CHETTY, KN

DRUMMOND, L

RAO, DSVS

DESAIAH, D

机构：

[1] UNIV MISSISSIPPI,MED CTR,DEPT SURG 1,JACKSON,MS 39216

[2] UNIV MISSISSIPPI,MED CTR,DEPT NEUROL 2,JACKSON,MS 39216

来源：

DRUG AND CHEMICAL TOXICOLOGY | 1979年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.3109/01480547909016031

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effects of preexposure of rats to cobaltous chloride (CO) mixed in iron-sufficient (I.S) and -deficient (I.D) diets on hepatic microsomal electron transfer system was investigated. Male Sprague-Dawley rats were fed for 4 weeks on I.D diets mixed with 0100 and 200 ppm CO. At the end of 4 weeks three rats from each group were transferred to I,S diets mixed with the same amount of CO. Liver microsomal NADPH - Cytochrome C reductase, NADPH - dehydrogenase, cytochrome P-450 and aniline binding were determined in both batches of rats. The rats receiving CO in the I.D diets showed a 35, 60, 75 and 40% decrease in NADPH -Cyt. C reductase, dehydrogenase, Cyt. P-450 and aniline binding respectively. The rats transferred from I.D diet to I. S diet showed a complete recovery of the inhibition of the microsomal electron transfer system. The rats receiving 200 ppm mixed with I.S diets did not show any changes in any biochemical parameter measured. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：375 / 381

页数：7

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