THE CORRELATION BETWEEN INTERLEUKIN-2 AND SOLUBLE INTERLEUKIN-2 RECEPTORS TO ESTRADIOL, PROGESTERONE AND TESTOSTERONE LEVELS IN PERIOVULATORY FOLLICLES OF INVITRO FERTILIZATION PATIENTS

被引：30

作者：

BARAK, V

MORDEL, N

ZAJICEK, G

KALICHMAN, I

TREVES, AJ

LAUFER, N

机构：

[1] Immunology Laboratory for Tumour Diagnosis, Hebrew University Hadassah Medical Centre, Jerusalem

[2] Department of Oncology, Hebrew University Hadassah Medical Centre, Jerusalem

[3] In Vitro Fertilization Unit, Department of Obstetrics and Gynaecology, Hebrew University Hadassah Medical Centre, Jerusalem

[4] H.Humphrey Centre for Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 07期

关键词：

CYTOKINES; FOLLICULAR FLUID; IL-2; IVF; SIL-2R;

D O I：

10.1093/oxfordjournals.humrep.a137772

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The present study was performed to evaluate the correlation between follicular fluid levels of interleukin 2 (IL-2) and IL-2 soluble receptor (sIL-2R), oestradiol, progesterone and testosterone levels, oocyte fertilization, embryo quality and pregnancy rates. Twenty-eight patients with a pure tubal factor and undergoing in-vitro fertilization and embryo transfer were randomly chosen and treated with gonadotrophin releasing hormone agonist (GnRHa) in the midluteal phase (long protocol) coupled with follicular phase administration of human menopausal gonadotrophin. Transvaginal follicular aspiration was performed 36 h after human chorionic gonadotrophin administration, followed 48 h later by embryo transfer. One hundred and twenty-three follicular fluids were sampled. The mean follicular fluid levels (+/- SD) were 2.30 +/- 0.80 fmol for IL-2, 458.2 +/- 236.0 units/ml for sIL-2R, 28.5 +/- 58.1 ng/ml for oestradiol, 2360.5 +/- 2846 ng/ml for progesterone and 7.22 +/- 7.08 ng/ml for testosterone. There was a significant (P < 0.01) correlation between IL-2 and testosterone levels. No correlation was found between the lymphokines and serum oestradiol, follicular fluid progesterone, oocyte fertilization, embryo quality and pregnancy. It may be concluded that significant concentrations of IL-2 and sIL-2R exist in follicular fluid. Wide variations in follicular IL-2 and sIL-2R concentrations of different follicles were found in the same patients.

引用

页码：926 / 929

页数：4

共 23 条

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