IMMOBILIZED ISOCYANATES FOR DERIVATIZATION OF AMINES FOR CHIRAL RECOGNITION IN LIQUID-CHROMATOGRAPHY WITH UV DETECTION

被引：12

作者：

BOURQUE, AJ

KRULL, IS

机构：

[1] NORTHEASTERN UNIV,DEPT CHEM,341 MUGAR BLDG,360 HUNTINGTON AVE,BOSTON,MA 02115

[2] NORTHEASTERN UNIV,BARNETT INST,BOSTON,MA 02115

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 06期

关键词：

LIQUID CHROMATOGRAPHY; SOLID-PHASE DERIVATIZATION; AMINES; PIRKLE PHASES; ISOCYANATES; ENANTIOMERS;

D O I：

10.1016/0731-7085(93)80163-U

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Solid-phase derivatization reagents containing a 3,5-dinitrophenyl moiety for the derivatization of amines are described. The reagents are useful for Pirkle-type recognition of stereochemical composition of amines and related nucleophiles. The ability to stabilize 3,5-dinitrophenylisocyanate by covalent immobilization on a polymeric support varied greatly with the support chosen. The kinetics of the activated dinitrophenylcarbamate and the use of this reagent for enhanced recognition of optical purity is shown and compared to previous findings with a similar polymeric activated ester.

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收藏

页码：495 / 503

页数：9

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