COMPARISON OF THE CHEMOSENSITIVITY OF A PRIMARY TUMOR AND ITS METASTASES USING A HUMAN-TUMOR XENOGRAFT

被引：20

作者：

SELBY, PJ

THOMAS, JM

PECKHAM, MJ

机构：

[1] INST CANC RES,DIV MED,SUTTON SM2 5PX,SURREY,ENGLAND

[2] INST CANC RES,DIV BIOPHYS,SUTTON SM2 5PX,SURREY,ENGLAND

[3] INST CANC RES,DIV RADIOTHERAPY,SUTTON SM2 5PX,SURREY,ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1979年 / 15卷 / 12期

关键词：

D O I：

10.1016/0014-2964(79)90020-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clonogenic cell survival curves were constructed for melphalan treatment of primary and secondary tumours of a human xenograft in immune deprived mice. The small metastases were shown to be more sensitive to melphalan than the larger primary tumours. Experiments with radiolabelled melphalan suggested that the greater sensitivity of the small tumours was due to better drug penetration. © 1979.

引用

页码：1425 / 1429

页数：5

共 16 条

[1] INVITRO COLONY ASSAY FOR HUMAN TUMORS GROWN IN IMMUNE-SUPPRESSED MICE AND TREATED INVIVO WITH CYTOTOXIC AGENTS [J].