STUDIES IN RED-BLOOD-CELL PRESERVATION .7. IN-VIVO AND IN-VITRO STUDIES WITH A MODIFIED PHOSPHATE-AMMONIUM ADDITIVE SOLUTION

被引:16
作者
GREENWALT, TJ
DUMASWALA, UJ
DHINGRA, N
ALLEN, CM
SILBERSTEIN, EB
机构
[1] Hoxworth Blood Center, University of Cincinnati Medical Center, Cincinnati, Ohio
关键词
D O I
10.1111/j.1423-0410.1993.tb02122.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Studies were conducted to examine whether an experimental an experimental additive solution (EAS-2) containing, in mM: 20 NH4Cl, 30 Na2HPO4, 2 adenine, 110 dextrose, 55 mannitol, pH 7.15, would be useful to extend the storage shelf life of human RBCs. With 6 pairs of split units, ATP concentrations were better maintained for 12 weeks with EAS-2 than with Adsol(R) (1.8 vs. 1.1 mumol/g Hb, respectively, p = 0.002). Autologous 24-hourS Cr-51 viability values for split units in the same donors were: on 6 paired units at 8 weeks, EAS-2 87.0+/-4.5%, Adsol 72.6+/-2.3%, p = 0.004; on 11 paired units at 9 weeks, EAS-2 79.5+/-7.1%, Adsol 68.2+/-10.1%, p = 0.0003. The data suggest that packed RBCs stored for 9 weeks with EAS-2 will be suitable for transfusion following the removal of supernatant with a single washing step.
引用
收藏
页码:87 / 94
页数:8
相关论文
共 44 条
[1]  
ADAMS H, 1963, METHOD ENZYMAT AN, P539
[2]  
ARNER B, 1964, ACTA MED SCAND, V176, P1
[3]  
BARTLETT GR, 1959, J BIOL CHEM, V234, P466
[4]   PRESERVATION OF RED CELL ATP - EFFECT OF PHOSPHATE [J].
BEUTLER, E ;
DURON, O .
TRANSFUSION, 1966, 6 (02) :124-&
[5]  
BEUTLER E, 1987, BLOOD, V70, P1389
[6]   EFFECT OF PH ON PRESERVATION OF RED CELL ATP [J].
BEUTLER, E ;
DURON, O .
TRANSFUSION, 1965, 5 (01) :17-+
[7]   REMOVAL OF YERSINIA-ENTEROCOLITICA FROM AS-1 RED-CELLS [J].
BUCHHOLZ, DH ;
AUBUCHON, JP ;
SNYDER, EL ;
KANDLER, R ;
EDBERG, S ;
PISCITELLI, V ;
PICKARD, C ;
NAPYCHANK, P .
TRANSFUSION, 1992, 32 (07) :667-672
[8]  
DAWSON RB, 1976, TRANSFUSION, V16, P450
[9]   BLOOD PRESERVATION .33. PHOSPHATE ENHANCEMENT OF RIBOSE MAINTENANCE OF 2,3-DPG AND ATP [J].
DAWSON, RB ;
SISK, LD ;
MEYER, DR ;
HERSHEY, RT ;
MYERSHILBERT, CS .
TRANSFUSION, 1981, 21 (02) :215-218
[10]  
DEBSKI B, 1985, Acta Physiologica Polonica, V36, P345