THE HUMAN Y-CHROMOSOME - A 43-INTERVAL MAP BASED ON NATURALLY-OCCURRING DELETIONS

被引：413

作者：

VOLLRATH, D ^{[1
]}

FOOTE, S ^{[1
]}

HILTON, A ^{[1
]}

BROWN, LG ^{[1
]}

BEERROMERO, P ^{[1
]}

BOGAN, JS ^{[1
]}

PAGE, DC ^{[1
]}

机构：

[1] MIT, DEPT BIOL, CAMBRIDGE, MA 02142 USA

来源：

SCIENCE | 1992年 / 258卷 / 5079期

关键词：

D O I：

10.1126/science.1439769

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A deletion map of the human Y chromosome was constructed by testing 96 individuals with partial Y chromosomes for the presence or absence of many DNA loci. The individuals studied included XX males, XY females, and persons in whom chromosome banding had revealed translocated, deleted, isodicentric, or ring Y chromosomes. Most of the 132 Y chromosomal loci mapped were sequence-tagged sites, detected by means of the polymerase chain reaction. These studies resolved the euchromatic region (short arm, centromere, and proximal long arm) of the Y chromosome into 43 ordered intervals, all defined by naturally occurring chromosomal breakpoints and averaging less than 800 kilobases in length. This deletion map should be useful in identifying Y chromosomal genes, in exploring the origin of chromosomal disorders, and in tracing the evolution of the Y chromosome.

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页码：52 / 59

页数：8

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