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EPSTEIN-BARR-VIRUS DNA RECOMBINES VIA LATENT ORIGIN OF REPLICATION WITH THE HUMAN GENOME IN THE LYMPHOBLASTOID CELL-LINE RGN1

被引：17
作者：
GUALANDI, G
SANTOLINI, E
CALEF, E
机构：
来源：
JOURNAL OF VIROLOGY | 1992年 / 66卷 / 09期
关键词：
D O I：
10.1128/JVI.66.9.5677-5681.1992
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We show here that in a lymphoblastoid cell line Epstein-Barr virus DNA recombines with the human genome. The genetic exchange involves the oriP region of the virus. A junction between viral and human DNA from this line has been cloned and sequenced. The results indicate that the integration of Epstein-Barr virus DNA involves a region of the human genome which contains internal short repetition. An 800-bp probe has been isolated from the human part of the junction. This probe has been used to show that the human region exists as a duplication in normal cells.
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页码：5677 / 5681
页数：5
相关论文
共 24 条
[1]  
ADAMS A, 1979, EPSTEINBARR VIRUS, P155
[2]   EVIDENCE FOR INTEGRATED EBV GENOMES IN RAJI CELLULAR DNA [J].
ANVRET, M ;
KARLSSON, A ;
BJURSELL, G .
NUCLEIC ACIDS RESEARCH, 1984, 12 (02) :1149-1161
[3]   SPECIFIC SITES FOR EBV ASSOCIATION IN THE NAMALWA BURKITT-LYMPHOMA CELL-LINE AND IN A LYMPHOBLASTOID LINE TRANSFORMED INVITRO WITH EBV [J].
CAPOROSSI, D ;
VERNOLE, P ;
PORFIRIO, B ;
TEDESCHI, B ;
FREZZA, D ;
NICOLETTI, B ;
CALEF, E .
CYTOGENETICS AND CELL GENETICS, 1988, 48 (04) :220-223
[4]  
DENTE L, 1985, DNA CLONING PRACTICA, V1, P101
[5]   A COMPREHENSIVE SET OF SEQUENCE-ANALYSIS PROGRAMS FOR THE VAX [J].
DEVEREUX, J ;
HAEBERLI, P ;
SMITHIES, O .
NUCLEIC ACIDS RESEARCH, 1984, 12 (01) :387-395
[6]   HIGH-EFFICIENCY TRANSFORMATION OF ESCHERICHIA-COLI BY HIGH-VOLTAGE ELECTROPORATION [J].
DOWER, WJ ;
MILLER, JF ;
RAGSDALE, CW .
NUCLEIC ACIDS RESEARCH, 1988, 16 (13) :6127-6145
[7]   A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].
FEINBERG, AP ;
VOGELSTEIN, B .
ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13
[8]  
GARGANO G, 1992, GENE CHROMOSOME CANC, V4, P205
[9]   IMMORTALIZATION OF MONKEY EPITHELIAL-CELLS BY SPECIFIC FRAGMENTS OF EPSTEIN-BARR VIRUS-DNA [J].
GRIFFIN, BE ;
KARRAN, L .
NATURE, 1984, 309 (5963) :78-82
[10]  
HALUSKA FG, 1989, PROG NUCLEIC ACID RE, V36, P269
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