DIRECT FORMATION OF (HALOARYL)COPPER NUCLEOPHILES FROM HALOIODOBENZENES AND ACTIVE COPPER

被引：11

作者：

EBERT, GW

PFENNIG, DR

SUCHAN, SD

DONOVAN, TA

AOUAD, E

TEHRANI, SS

GUNNERSEN, JN

DONG, LM

机构：

[1] Department of Chemistry, State University of New York College, Buffalo, New York 14222, Buffalo

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 08期

关键词：

D O I：

10.1021/jo00113a013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(o-Halophenyl)-; (m-halophenyl)-, and (p-halophenyl)copper reagents have been formed in moderate to high yields at room temperature from active copper and the corresponding haloiodobenzenes. These reagents have been cross-coupled with a variety of alkyl and acyl halides to produce the respective haloarenes and haloaryl ketones. Remarkably, (o-fluorophenyl)- and (o-chlorophenyl)copper are produced in good yields by this procedure without undergoing elimination to form benzyne making this approach a convenient method for generating o-halophenyl nucleophiles.

引用

页码：2361 / 2364

页数：4

共 46 条

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