PHYSICOCHEMICAL PROPERTIES OF THE FLUOROQUINOLONE ANTIMICROBIALS .5. EFFECT OF FLUOROQUINOLONE STRUCTURE AND PH ON THE COMPLEXATION OF VARIOUS FLUOROQUINOLONES WITH MAGNESIUM AND CALCIUM-IONS

被引：61

作者：

ROSS, DL ^{[1
]}

RILEY, CM ^{[1
]}

机构：

[1] UNIV KANSAS,DEPT PHARMACEUT CHEM,LAWRENCE,KS 66045

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 93卷 / 1-3期

关键词：

FLUOROQUINOLONE; ANTIMICROBIALS; METAL-ION COMPLEXATION; FLUORESCENCE; STRUCTURAL EFFECTS;

D O I：

10.1016/0378-5173(93)90170-K

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The complexation of nalidixic acid and nine 7-piperazinylfluoroquinolone antimicrobials with magnesium and calcium ions was studied at room temperature (22 +/- 1-degrees-C) by spectrofluorometry. Scatchard plots were used to determined the stoichiometry of binding and the effects of pH were investigated to determine which Bjerrum species of the compounds bound most tightly to the metal ions. Multiple regression analysis was used to determine the relationship between the association constants and the binding to magnesium ions. The results of that analysis were then used to propose a structure for the 2:2 complex of magnesium and lomefloxacin.

引用

收藏

页码：121 / 129

页数：9

相关论文

共 34 条

[1] THE COMPLEXATION OF TRANSITION SERIES METAL-IONS BY NALIDIXIC-ACID AND RELATED METHOXYQUINOLONES - ITS INFLUENCE ON PARTITION-COEFFICIENTS WITH REFERENCE TO ANTIBACTERIAL ACTIVITY [J].

BAILEY, AJG ;

COLE, A ;

GOODFIELD, J ;

MAY, PM ;

DREYFUSS, ME ;

MIDGLEY, JM ;

WILLIAMS, DR .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1984, 22 (2-3) :283-290

[2] INFLUENCE OF URINARY PH ON THE PHARMACOKINETICS OF CINOXACIN IN HUMANS AND ON ANTIBACTERIAL ACTIVITY INVITRO [J].

BARBHAIYA, RH ;

GERBER, AU ;

CRAIG, WA ;

WELLING, PG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1982, 21 (03) :472-480

[3] METAL-COMPLEXES OF THE ANTIBIOTIC NALIDIXIC-ACID [J].

BEHRENS, NB ;

DIAZ, GM ;

GOODGAME, DML .

INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1986, 125 (01) :21-26

[4] COMPARATIVE-STUDY ON ANTAGONISTIC EFFECTS OF LOW PH AND CATION SUPPLEMENTATION ON INVITRO ACTIVITY OF QUINOLONES AND AMINOGLYCOSIDES AGAINST PSEUDOMONAS-AERUGINOSA [J].

BLASER, J ;

LUTHY, R .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 22 (01) :15-22

[5] DECREASED CIPROFLOXACIN ABSORPTION WITH CONCOMITANT ADMINISTRATION OF FERROUS FUMARATE [J].

BROUWERS, JRBJ ;

VANDERKAM, HJ ;

SIJTSMA, J ;

PROOST, JH .

PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1990, 12 (05) :182-183

[6] THE COMPLEXATION OF TRANSITION SERIES METAL-IONS BY NALIDIXIC-ACID [J].

COLE, A ;

GOODFIELD, J ;

WILLIAMS, DR ;

MIDGLEY, JM .

INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1984, 92 (02) :91-97

[7]

COTTON AF, 1980, ADV INORG CHEM RAD, P283

[8] EFFECTS OF MAGNESIUM-ALUMINUM HYDROXIDE AND CALCIUM-CARBONATE ANTACIDS ON BIOAVAILABILITY OF OFLOXACIN [J].

FLOR, S ;

GUAY, DRP ;

OPSAHL, JA ;

TACK, K ;

MATZKE, GR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (12) :2436-2438

[9]

FLOR S, 1985, RECENT ADV CHEMOTHER, P1783

[10] THE EFFECT OF SINGLE INTRAVENOUS DOSES OF CIMETIDINE OR RANITIDINE ON GASTRIC-SECRETION [J].

FRANK, WO ;

PEACE, KE ;

WATSON, M ;

SEAMAN, JJ ;

SZEGO, PL ;

BRAVERMAN, A ;

MICO, B ;

DICKSON, B .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1986, 40 (06) :665-672

← 1 2 3 4 →