PHYSIOLOGY OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN HEALTH AND DYSREGULATION IN PSYCHIATRIC AND AUTOIMMUNE DISORDERS

被引：135

作者：

TSIGOS, C

CHROUSOS, GP

机构：

[1] NIH, PEDIAT ENDOCRINOL SECT, DEV ENDOCRINOL BRANCH, BETHESDA, MD USA

[2] NIH, PEDIAT ENDOCRINOL TRAINING PROGRAM, BETHESDA, MD USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1994年 / 23卷 / 03期

关键词：

D O I：

10.1016/S0889-8529(18)30078-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The hypothalamic-pituitary-adrenal (HPA) axis is the endocrine limb of the ''stress system'' that, together with the sympathetic nervous system, plays a crucial role in maintaining homeostasis. This article briefly reviews current knowledge on the physiology of the HPA axis, including the regulation of its principle modulators, CRH and arginine vasopressin, its interactions with the immune system and other endocrine axes, and its altered regulation or dysregulation in various physiologic and pathophysiologic states, respectively.

引用

页码：451 / 466

页数：16

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