CLADISTIC-ANALYSIS OF THE APOLIPOPROTEIN AI-CIII-AIV GENE-CLUSTER USING A HEALTHY FRENCH-CANADIAN SAMPLE .1. HAPLOID ANALYSIS

被引：13

作者：

HAVILAND, MB

KESSLING, AM

DAVIGNON, J

SING, CF

机构：

[1] ST MARYS HOSP, SCH MED, DEPT BIOCHEM, LONDON, ENGLAND

[2] ST MARYS HOSP, SCH MED, DEPT MOLEC GENET, LONDON, ENGLAND

[3] CLIN RES INST MONTREAL, HYPERLIPIDEMIA & ATHEROSCLEROSIS RES GRP, MONTREAL, PQ H2W 1R7, CANADA

来源：

ANNALS OF HUMAN GENETICS | 1995年 / 59卷

关键词：

D O I：

10.1111/j.1469-1809.1995.tb00742.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A cladistic analysis was carried out to identify haplotypes hypothesized to differ for functional DNA sequence variations within the apolipoprotein (ape) AI-CIII-AIV gene cluster that affect plasma lipid, lipoprotein and apolipoprotein levels. A sample of unrelated healthy French Canadians was studied. First, a cladogram of the observed apo AI-CIII-AIV haplotypes was estimated. Then this cladogram was used to define a statistical analysis of the association between haplotype variation and variation in plasma lipid, lipoprotein and apolipoprotein levels. Three haplotypes were identified which were associated with small (5-12% of the total sum of squares) pleiotropic effects on plasma lipid, lipoprotein and apolipoprotein traits and these effects were context, i.e. gender, dependent.

引用

页码：211 / 231

页数：21

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