EVIDENCE FOR MULTIPLE PRECURSOR CELL-TYPES IN THE EMBRYONIC RAT CEREBRAL-CORTEX

被引：148

作者：

WILLIAMS, BP ^{[1
]}

PRICE, J ^{[1
]}

机构：

[1] NATL INST MED RES,LONDON NW7 1AA,ENGLAND

来源：

NEURON | 1995年 / 14卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0896-6273(95)90265-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell lineage studies of the rat cerebral cortex suggest that by midneurogenesis, most precursor cells of the ventricular zone are specified to produce a single cell type. Yet there is also evidence for multipotential precursor cells. We used a retroviral vector to follow the developmental potential of cortical precursor cells by labeling cortical cells in cultures from embryos between 12 and 18 days of gestation. We found specified precursor cells as early as embryonic day 12, in addition to bipotential cells that generate neurons and astrocytes. Most importantly, we discovered a type of neural precursor cell, a neuroepithelial cell, that predominates earlier in development, differs distinctly from the specified precursor cells, and as a population, appears to be multipotential. These data suggest that corticogenesis progresses from an early phase dominated by neuroepithelial cells to a rater phase characterized by multiple populations of specified precursor cells.

引用

页码：1181 / 1188

页数：8

共 29 条

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