COMPARISON OF THE TOXA TEST WITH CYTOTOXICITY ASSAY AND CULTURE FOR THE DETECTION OF CLOSTRIDIUM-DIFFICILE-ASSOCIATED DIARRHEAL DISEASE

被引：23

作者：

SCHUE, V ^{[1
]}

GREEN, GA ^{[1
]}

MONTEIL, H ^{[1
]}

机构：

[1] UNIV LOUIS PASTEUR,FAC MED,BACTERIOL LAB,TOXINOL BACTERIENNE LAB,F-67000 STRASBOURG,FRANCE

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1994年 / 41卷 / 05期

关键词：

D O I：

10.1099/00222615-41-5-316

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Stool samples (355 from 350 patients) were examined in a new commercial assay, the ToxA test, for the rapid diagnosis of Clostridium difficile-associated diarrhoea. The results were compared with direct assay of cytotoxin in McCoy cell tissue culture, and detection of toxigenic C. difficile by culture and cytotoxin testing of isolates. Discordant results were resolved by consultation of clinical records. Test sensitivities were 84.6 % for the ToxA test, 78.5 % for the direct cytotoxicity assay and 95.4 % for culture. The specificity was 100 % for all the tests. The ToxA test is a rapid and reliable alternative for the detection of toxigenic C. difficile where tissue culture facilities are unavailable.

引用

页码：316 / 318

页数：3

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