NITRIC-OXIDE MODULATES GAMMA-INTERFERON-INDUCED MHC CLASS-II ANTIGEN EXPRESSION ON RAT ASTROCYTES

被引：26

作者：

HEUSCHLING, P

机构：

[1] Neuroimmunology and Inflammation, Centre de Recherche Public de la Santé, L-1150 Luxembourg, 120, route d'Arlon

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1995年 / 57卷 / 1-2期

关键词：

ASTROCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II; NITRIC OXIDE; CGMP; GLUTAMATE; NOREPINEPHRINE;

D O I：

10.1016/0165-5728(94)00162-H

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Brain astroglial cells can be brought in vivo and in vitro to express an immunocompetent cell-like phenotype. We investigated the effect of the NO. releasing compound sodium nitroprusside (SNP) on Ia expression in rat astrocyte cultures. SNP down-regulates, in a concentration-dependent manner, the gamma-interferon-induced Ia expression. Inhibition of the NO. synthesis attenuates the glutamate mediated down-regulation of class II expression. Our results show that NO. is implicated in the immunomodulatory reactions in the brain parenchyma.

引用

页码：63 / 69

页数：7

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