SERUM IMMUNOREACTIVE SOMATOMEDIN-C IS ELEVATED LATE IN PREGNANCY

被引：102

作者：

FURLANETTO, RW

UNDERWOOD, LE

VANWYK, JJ

HANDWERGER, S

机构：

[1] UNIV N CAROLINA, SCH MED, DEPT PEDIAT, CHAPEL HILL, NC 27514 USA

[2] DUKE UNIV, MED CTR, DEPT PEDIAT, DURHAM, NC 27710 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1978年 / 47卷 / 03期

关键词：

D O I：

10.1210/jcem-47-3-695

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The concentrations of immunoreactive somatomedin-C (Sm-C) in the sera of women with uncomplicated pregnancies were found to be progressively higher as the duration of gestation increased. Between 19 and 42 weeks of gestation, there was a significant correlation between serum Sm-C concentration and duration of gestation. A striking decline in Sm-C was observed following delivery. While the data are too preliminary to elucide the mechanisms for the raised Sm-C, the concurrent increase in Sm-C and human placental lactogen (hPL) raises the possibility that hPL may mediate the increment in Sm-C. © 1978 by The Endocrine Society.

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页码：695 / 698

页数：4

相关论文

共 16 条

[1] SOMATOMEDIN BIOACTIVITY IN SERUM AND AMNIOTIC-FLUID DURING PREGNANCY [J].

BALA, RM ;

WRIGHT, C ;

BARDAI, A ;

SMITH, GR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1978, 46 (04) :649-652

[2] CHARACTERIZATION OF A PROTEIN IN MID-TERM HUMAN AMNIOTIC-FLUID WHICH REACTS IN SOMATOMEDIN-C RADIORECEPTOR ASSAY [J].

CHOCHINOV, RH ;

MARIZ, IK ;

HAJEK, AS ;

DAUGHADAY, WH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1977, 44 (05) :902-908

[3] AMNIOTIC-FLUID REACTIVITY DETECTED BY SOMATOMEDIN C RADIORECEPTOR ASSAY - CORRELATION WITH GROWTH-HORMONE, PROLACTIN AND FETAL RENAL MATURATION [J].

CHOCHINOV, RH ;

KETUPANYA, A ;

MARIZ, IK ;

UNDERWOOD, LE ;

DAUGHADAY, WH .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1976, 42 (05) :983-986

[4] SECRETION AND DISPOSITION OF CORTISOL DURING PREGNANCY [J].

COHEN, M ;

STIEFEL, M ;

REDDY, WJ ;

LAIDLAW, JC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1958, 18 (10) :1076-1092

[5] MAINTENANCE OF SERUM SOMATOMEDIN ACTIVITY IN HYPOPHYSECTOMIZED PREGNANT RATS [J].

DAUGHADAY, WH ;

KAPADIA, M .

ENDOCRINOLOGY, 1978, 102 (04) :1317-1320

[6] PROLACTIN-STIMULATED PRODUCTION OF SOMATOMEDIN BY RAT-LIVER [J].

FRANCIS, MJO ;

HILL, DJ .

NATURE, 1975, 255 (5504) :167-168

[7] ESTIMATION OF SOMATOMEDIN-C LEVELS IN NORMALS AND PATIENTS WITH PITUITARY DISEASE BY RADIOIMMUNOASSAY [J].

FURLANETTO, RW ;

UNDERWOOD, LE ;

VANWYK, JJ ;

DERCOLE, AJ .

JOURNAL OF CLINICAL INVESTIGATION, 1977, 60 (03) :648-657

[8]

HANDWERGER S, 1974, HUMAN PLACENTAL LACT

[9] ACTION OF RAT PROLACTIN ON PLASMA SOMATOMEDIN LEVELS IN RAT AND ON SOMATOMEDIN RELEASE FROM PERFUSED RAT-LIVER [J].

HILL, DJ ;

FRANCIS, MJO ;

MILNER, RDG .

JOURNAL OF ENDOCRINOLOGY, 1977, 75 (01) :137-143

[10] OVINE PLACENTAL LACTOGEN INDUCES SOMATOMEDIN - POSSIBLE ROLE IN FETAL GROWTH [J].

HURLEY, TW ;

DERCOLE, AJ ;

HANDWERGER, S ;

UNDERWOOD, LE ;

FURLANETTO, RW ;

FELLOWS, RE .

ENDOCRINOLOGY, 1977, 101 (05) :1635-1638