RADIOIMMUNOLOGIC LOCALIZATION OF VASOACTIVE INTESTINAL POLYPEPTIDE IN HYPOTHALAMIC AND EXTRAHYPOTHALAMIC SITES IN THE RAT-BRAIN

被引：99

作者：

SAMSON, WK

SAID, SI

MCCANN, SM

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT INTERNAL MED,DALLAS,TX 75235

[2] UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,DALLAS,TX 75235

[3] VET ADM HOSP,DALLAS,TX 75216

来源：

NEUROSCIENCE LETTERS | 1979年 / 12卷 / 2-3期

关键词：

D O I：

10.1016/0304-3940(79)96073-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using a specific radioimmunoassay (RIA), we have quantitated the hypothalamic and extrahypothalamic distribution of vasoactive intestinal polypeptide (VIP) in th rat brain. Highest concentrations of VIP were found in cerebral cortex, suprachiasmatic nucleus, and medial amygdaloid nucleus. Lower concentrations were found in the anterior hypothalamic area, medial preoptic area, peri- and paraventricular nuclei, and hippocampus. Significant levels of VIP were also found in the anterior pituitary. Very little VIP was detected in median eminence and cerebellar cortex. This distribution of VIP in areas of the rat brain known to be important to neuroendocrine function suggests a role for VIP in the control of anterior pituitary events. © 1979.

引用

页码：265 / 269

页数：5

共 17 条

[1]

[Anonymous], FRONT NEUROENDOCRIN

[2]

ANTUNESR.J, 1970, P SOC EXP BIOL MED, V133, P1464

[3]

BROWNSTEIN MJ, 1977, PEPTIDES NEUROBIOLOG, P145

[4] VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) - VESICULAR LOCALIZATION AND POTASSIUM EVOKED RELEASE FROM RAT HYPOTHALAMUS [J].