PROTEASE ACTIVITY ON THE SURFACE OF HSV-INFECTED CELLS

被引：10

作者：

DIERICH, MP ^{[1
]}

LANDEN, B ^{[1
]}

SCHULZ, T ^{[1
]}

FALKE, D ^{[1
]}

机构：

[1] UNIV MAINZ,DIV EXPTL VIROL,D-6500 MAINZ,FED REP GER

来源：

JOURNAL OF GENERAL VIROLOGY | 1979年 / 45卷 / OCT期

关键词：

D O I：

10.1099/0022-1317-45-1-241

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Monolayers of primary rabbit kidney cells infected with HSV type I bound lymphoblastoid (Raji) cells, to which the third component (C3) of the complement system had been attached (Raji-C3). This induction of cell contact did not occur on non-infected monolayers and was dependent on C3. The interaction could be suppressed by the presence of protease inhibitors (ImM-TLCK or-PMSF). The results are interpreted as indicating de novo expression of protease activity on the surface of HSV-infected cells. This protease is characterized by its potential to activate C3 and its inhibition by TLCK.

引用

页码：241 / 244

页数：4

共 23 条

[1] 3RD COMPONENT OF COMPLEMENT (C3) - STRUCTURAL-PROPERTIES IN RELATION TO FUNCTIONS [J].