THE ROLE OF INSULIN-LIKE GROWTH-FACTORS AND IGF-BINDING PROTEINS IN THE PHYSIOLOGICAL AND PATHOLOGICAL PROCESSES OF THE KIDNEY

被引：41

作者：

ZUMKELLER, W

SCHOFIELD, PN

机构：

[1] UNIV LONDON, INST CHILD HLTH, LONDON, ENGLAND

[2] UNIV CAMBRIDGE, DEPT ANAT, CAMBRIDGE, ENGLAND

来源：

VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY | 1992年 / 62卷 / 04期

关键词：

INSULIN-LIKE GROWTH FACTORS; IGF-BINDING PROTEINS; IGF-RECEPTORS; RENAL PHYSIOLOGY; RENAL PATHOLOGY;

D O I：

10.1007/BF02899684

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Insulin-like growth factors (IGFs) and their binding proteins are implicated in the growth regulation of the kidney during embryogenesis and differentiation. Recent evidence also suggests that IGFs play a role in kidney physiology (glomerular filtration rate, renal plasma flow) and pathology (diabetic renal hypertrophy, nephritis, glomerulosclerosis, kidney tumours, chronic renal failure). This review focuses on the biology of IGFs at the molecular, protein and receptor levels and considers their importance in renal physiology and pathology. The current data demonstrate a central role for the IGFs in the mediation of a wide variety of effects on renal growth, function and malignancy.

引用

页码：207 / 220

页数：14

共 228 条

[1] INSULIN AND INSULIN-LIKE GROWTH FACTOR-I BINDING TO CULTURED RAT GLOMERULAR MESANGIAL CELLS [J].