BUPROPION AND ALCOHOL FATAL INTOXICATION - CASE-REPORT

被引：23

作者：

RAMCHARITAR, V ^{[1
]}

LEVINE, BS ^{[1
]}

GOLDBERGER, BA ^{[1
]}

CAPLAN, YH ^{[1
]}

机构：

[1] OFF CHIEF MED EXAMINER,BALTIMORE,MD 21201

来源：

FORENSIC SCIENCE INTERNATIONAL | 1992年 / 56卷 / 02期

关键词：

BUPROPION; METABOLISM; FATAL INTOXICATION; GAS CHROMATOGRAPHY/MASS SPECTROMETRY;

D O I：

10.1016/0379-0738(92)90173-T

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A fatality due to the ingestion of bupropion and ethanol is presented. Bupropion and its metabolites were extracted from several tissues and identified using gas chromatography with nitrogen-phosphorus and mass spectrometry detection. The concentrations of bupropion, hydroxybupropion and the erythroamino and threoamino alcohol metabolites in heart blood were 4.2, 5.0, 0.6 and 4.6 mg/l, respectively. The heart blood ethanol concentration was 0.27 g/dl. In addition, bupropion was distributed as follows: subclavian blood, 6.2 mg/l; bile, 1.4 mg/l; kidney, 2.4 mg/l; liver, 1.0 mg/kg; stomach contents, 16 mg and urine, 37 mg/l.

引用

页码：151 / 156

页数：6