ISOTYPIC ANALYSIS OF GRASS-POLLEN-SPECIFIC IMMUNOGLOBULINS IN HUMAN PLASMA .2. QUANTIFICATION OF THE IGE, IGM, IGA CLASS AND THE IGG SUBCLASS ANTIBODIES

被引:11
作者
BATARD, T
BASUYAUX, B
LAROZE, A
LAMBIN, P
BREMARDOURY, C
AUCOUTURIER, P
HAMILTON, RG
DAVID, B
PELTRE, G
机构
[1] INST PASTEUR,UNITE IMMUNOALLERGIE,28 RUE DR ROUX,F-75724 PARIS 15,FRANCE
[2] CTR NATL TRANSFUS SANGUINE,DIV RECH & DEV PROTEINES PLASTMAT,LES ULIS,FRANCE
[3] INST NATL TRANSFUS SANGUINE,PARIS,FRANCE
[4] UNIV POITIERS,F-86034 POITIERS,FRANCE
[5] JOHNS HOPKINS UNIV,SCH MED,DEPT MED,DIV CLIN IMMUNOL,BALTIMORE,MD 21205
关键词
GRASS POLLEN; DACTYLIS-GLOMERATA (COCKSFOOT); HUMAN HUMORAL IMMUNE RESPONSE; IGE; IGM; IGA; IGG1-4; QUANTIFICATION; CH GENE;
D O I
10.1159/000236537
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Previously, the specificity of human immune responses to Dactylis pollen was analyzed in 26 plasma samples with high levels of grass-pollen-specific IgG4 ('IgG4+ plasma', largely from grass-pollen-allergic patients), as compared to 25 plasma samples with low grass-pollen-specific IgG4 ('normal plasma', from nonatopic individuals). In the present study, a quantification of the Dactylis-pollen-specific IgE, IgM, IgA class and IgG subclass antibodies in these plasma samples is proposed. Isotypic distribution in IgG4+ plasma was 68% IgG [IgG2 (38%) > IgG4 (30%) > IgG1 (19%) > IgG3 (13%)], 27% IgM, 4% IgA and 0.05% IgE. In normal plasma it was 73% IgM, 20% IgG [IgG3 (38%) > IgG2 (33%) > IgG1 (29%) > IgG4 (0%)],6% IgA and 0.006% IgE. In IgG4+ plasma, specific IgE, IgG1, IgG2 and IgG4 concentrations were positively correlated between each other. Finally, the present study clearly confirmed the possible role of the C(H) gene regulation in allergic diseases.
引用
收藏
页码:279 / 287
页数:9
相关论文
共 41 条
[1]  
AALBERSE RC, 1983, J IMMUNOL, V130, P722
[2]  
ADKINSON NF, 1979, J IMMUNOL, V122, P965
[3]   ISOTYPIC ANALYSIS OF GRASS POLLEN-SPECIFIC IMMUNOGLOBULINS IN HUMAN PLASMA .1. SPECIALIZATION OF CERTAIN CLASSES AND SUBCLASSES IN THE IMMUNE-RESPONSE [J].
BATARD, T ;
BASUYAUX, B ;
LAMBIN, P ;
BREMARDOURY, C ;
HAMILTON, RG ;
DAVID, B ;
PELTRE, G .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1993, 100 (01) :68-78
[4]   INTERLEUKIN-4 INDUCES CHANGES IN THE CHROMATIN STRUCTURE OF THE GAMMA-1 SWITCH REGION IN RESTING B-CELLS BEFORE SWITCH RECOMBINATION [J].
BERTON, MT ;
VITETTA, ES .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (01) :375-378
[5]   PURIFIED PROTEIN DERIVATIVE OF MYCOBACTERIUM-TUBERCULOSIS AND EXCRETORY-SECRETORY ANTIGEN(S) OF TOXOCARA-CANIS EXPAND INVITRO HUMAN T-CELLS WITH STABLE AND OPPOSITE (TYPE-1 T-HELPER OR TYPE-2 T-HELPER) PROFILE OF CYTOKINE PRODUCTION [J].
DELPRETE, GF ;
DECARLI, M ;
MASTROMAURO, C ;
BIAGIOTTI, R ;
MACCHIA, D ;
FALAGIANI, P ;
RICCI, M ;
ROMAGNANI, S .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 88 (01) :346-350
[6]   IGG SUBCLASSES OF ANTIBODIES TO GRASS POLLEN ALLERGENS PRODUCED IN HAY-FEVER PATIENTS DURING HYPOSENSITIZATION [J].
DEVEY, ME ;
WILSON, DV ;
WHEELER, AW .
CLINICAL ALLERGY, 1976, 6 (03) :227-236
[7]   THE IGE AND IGG SUBCLASS ANTIBODY-RESPONSE IN PATIENTS ALLERGIC TO YELLOW JACKET VENOM UNDERGOING DIFFERENT REGIMENS OF VENOM IMMUNOTHERAPY [J].
DJURUP, R ;
MALLING, HJ ;
SONDERGAARD, I ;
WEEKE, B .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1985, 76 (01) :46-55
[8]  
DURHAM SR, 1992, J IMMUNOL, V148, P2390
[9]  
GASCAN H, 1991, J IMMUNOL, V147, P8
[10]   IMMUNOGLOBULIN SUBCLASS DISTRIBUTION OF SPECIFIC ANTIBODIES IN ALLERGIC PATIENTS - PREDICTION OF THE IGE INDUCING CAPACITY OF POTENTIAL ALLERGENS [J].
HAMMARSTROM, L ;
SMITH, CIE .
ALLERGY, 1987, 42 (07) :529-534