THE ZARAGOZIC ACIDS - STRUCTURE ELUCIDATION OF A NEW CLASS OF SQUALENE SYNTHASE INHIBITORS

被引：61

作者：

HENSENS, OD

DUFRESNE, C

LIESCH, JM

ZINK, DL

REAMER, RA

VANMIDDLESWORTH, F

机构：

[1] Merck Research Laboratories, Rahway, NJ 07065-0900

[2] Glaxo Research Laboratories, Research Triangle Park

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 03期

关键词：

ZARAGOZIC ACID-A AND ACID-B; SQUALENE SYNTHASE INHIBITORS; 2D NMR; SPOROMIELLA-INTERMEDIA; LEPTODONTIIUM-ELATIUS;

D O I：

10.1016/0040-4039(93)85086-C

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Structures of two novel fungal metabolites, zaragozic acids A (1) and B (2), characterized by a novel 2,8-dioxobicyclo[3.2.1]octane-4,6,7-trihydroxy-3,4,5-tricarboxylic acid core, are proposed predominantly on the basis of 2D NMR.

引用

页码：399 / 402

页数：4

共 10 条

[1] BARTIZAL KF, 1991, Patent No. 5026554
[2] LONG-RANGE PROTON C-13 NMR SPIN COUPLING-CONSTANTS
BAX, A
FREEMAN, R
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (04) : 1099 - 1100
[3] BERGSTROM JD, UNPUB P NAT ACAD SCI
[4] REGRESSION OF CORONARY-ARTERY DISEASE AS A RESULT OF INTENSIVE LIPID-LOWERING THERAPY IN MEN WITH HIGH-LEVELS OF APOLIPOPROTEIN-B
BROWN, G
ALBERS, JJ
FISHER, LD
SCHAEFER, SM
LIN, JT
KAPLAN, C
ZHAO, XQ
BISSON, BD
FITZPATRICK, VF
DODGE, HT
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (19) : 1289 - 1298
[5] GRUNDY SM, 1988, NEW ENGL J MED, V319, P24
[6] KALINOWSKI E, 1988, CARBON 13 NMR SPECTR, P132
[7] 1,6-ANHYDROFURANOSES .19. H-1 NMR-SPECTRA AND C-13 NMR-SPECTRA OF 1,6-ANHYDROHEXOFURANOSES
KOLL, P
ANGYAL, SJ
[J]. CARBOHYDRATE RESEARCH, 1988, 179 : 1 - 5
[8] CONFIGURATIONAL EFFECTS ON C-13 CHEMICAL-SHIFTS OF 1,6-ANHYDROHEXOPYRANOSES AND RELATED COMPOUNDS - UTILITY OF C-13-H-1 COUPLING PATTERNS FOR SIGNAL ASSIGNMENTS
RITCHIE, RGS
CYR, N
PERLIN, AS
[J]. CANADIAN JOURNAL OF CHEMISTRY, 1976, 54 (14) : 2301 - 2309
[9] THE SQUALESTATINS, NOVEL INHIBITORS OF SQUALENE SYNTHASE PRODUCED BY A SPECIES OF PHOMA .2. STRUCTURE ELUCIDATION
SIDEBOTTOM, PJ
HIGHCOCK, RM
LANE, SJ
PROCOPIOU, PA
WATSON, NS
[J]. JOURNAL OF ANTIBIOTICS, 1992, 45 (05) : 648 - 658
[10] WILSON K, IN PRESS J ORG CHEM

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