FATTY-ACID PRODUCTION CHARACTERISTICS OF FUNGI WITH PARTICULAR EMPHASIS ON GAMMA-LINOLENIC ACID PRODUCTION

被引:43
作者
KENNEDY, MJ
READER, SL
DAVIES, RJ
机构
[1] New Zealand Institute for Industrial Research and Development, Lower Hutt
关键词
POLYUNSATURATED FATTY ACID (PUFA); MICROBIAL OIL; GAMMA-LINOLENIC ACID (GLA); PRODUCTION; FERMENTATION;
D O I
10.1002/bit.260420511
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The fatty acid production characteristics of fungi are described. These characteristics are the relationship between the oil content of the cell and the fatty acid content of the oil. For example, for polyunsaturated fatty acid (PUFA) production by Mucor hiemalis IPD 51, the oil content of the cell and the GLA content of the oil are coupled. For fungal production of some PUFA, synthesized after the rate-limiting step in the fatty acid anabolic chain, a maximum fatty acid production model was developed to link the fatty acid content of the oil and the oil content of the cell. Maximum volumetric productivity of gamma linolenic acid (GLA) by molds was found to occur at a specific GLA content of the oil. For example, for M. hiemalis IPD 51, a maximum volumetric of 4.7 mg GLA/L . h was produced at a GLA content of the oil of 8% to 10%. Similarly for Mucor circinelloides v. Tieghem IPD 155 a maximum volumetric productivity of 4.8 mg GLA/L . h was produced at a GLA content of the oil of 14% to 16%. These results imply that, when screening microorganisms for GLA or other fatty acid production, a number of medium compositions need to be evaluated to determine the tradeoff between oil content of the cell and fatty acid content of the oil. (C) 1993 John Wiley & Sons, Inc.
引用
收藏
页码:625 / 634
页数:10
相关论文
共 59 条
[1]   LIPID AND FATTY-ACID COMPOSITION OF SELECTED FUNGI GROWN ON WHEY MEDIUM [J].
ABRAHAM, MJ ;
SRINIVASAN, RA .
JOURNAL OF FOOD SCIENCE, 1984, 49 (03) :950-951
[2]   EFFECTS OF OXYGEN AND GLUCOSE LEVELS ON LIPID COMPOSITION OF YEAST CANDIDA UTILIS GROWN IN CONTINUOUS CULTURE [J].
BABIJ, T ;
MOSS, FJ ;
RALPH, BJ .
BIOTECHNOLOGY AND BIOENGINEERING, 1969, 11 (04) :593-&
[3]   EFFECTS OF AGING MORTIERELLA MYCELIUM ON PRODUCTION OF ARACHIDONIC AND EICOSAPENTAENOIC ACIDS [J].
BAJPAI, P ;
BAJPAI, PK ;
WARD, OP .
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1991, 68 (10) :775-780
[4]   OPTIMIZATION OF PRODUCTION OF DOCOSAHEXAENOIC ACID (DHA) BY THRAUSTOCHYTRIUM-AUREUM ATCC 34304 [J].
BAJPAI, PK ;
BAJPAI, P ;
WARD, OP .
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1991, 68 (07) :509-514
[5]  
Barber AT, 1988, PHARM J, V240, P723
[6]  
BRENNER R R, 1981, Progress in Lipid Research, V20, P41, DOI 10.1016/0163-7827(81)90012-6
[7]   EFFECT OF ARACHIDONIC ACID IN ALLOXAN-DIABETIC RAT [J].
BRENNER, RR ;
PELUFFO, RO ;
MERCURI, O ;
RESTELLI, MA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1968, 215 (01) :63-+
[8]  
BRENNER RR, 1989, ROLE FATS HUMAN NUTR, P45
[9]   PRODUCTION OF MICROBIAL LIPID - EFFECTS OF GROWTH-RATE AND OXYGEN ON LIPID-SYNTHESIS AND FATTY-ACID COMPOSITION OF RHODOTORULA-GRACILIS [J].
CHOI, SY ;
RYU, DDY ;
RHEE, JS .
BIOTECHNOLOGY AND BIOENGINEERING, 1982, 24 (05) :1165-1172
[10]   OVERPRODUCTION OF GAMMA-LINOLENIC AND EICOSAPENTAENOIC ACIDS BY ALGAE [J].
COHEN, Z ;
DIDI, S ;
HEIMER, YM .
PLANT PHYSIOLOGY, 1992, 98 (02) :569-572