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THERAPEUTIC MONITORING OF RAPAMYCIN - A NEW IMMUNOSUPPRESSIVE DRUG

被引：31
作者：
YATSCOFF, RW
LEGATT, DF
KNETEMAN, NM
机构：
[1] UNIV ALBERTA,DEPT LAB MED & PATHOL,EDMONTON T6G 2E1,ALBERTA,CANADA
[2] UNIV ALBERTA,DEPT PATHOL,EDMONTON T6G 2E1,ALBERTA,CANADA
来源：
THERAPEUTIC DRUG MONITORING | 1993年 / 15卷 / 06期
关键词：
RAPAMYCIN; IMMUNOSUPPRESSIVE EFFICACY; PHARMACOKINETICS; BLOOD DISTRIBUTION; THERAPEUTIC MONITORING;
D O I：
10.1097/00007691-199312000-00004
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Rapamycin (RAPA) is a new immunosuppressive drug with a potency similar to that of FK506 and up to a 100-fold greater than that of cyclosporine (CsA). RAPA has shown to be efficacious in the prolongation of allograft survival in a number of animal models. In early studies, RAPA was administered on a dose/weight basis, with little attention given to its effective blood concentration. Details describing the approaches used to establish a therapeutic range for the drug in animal transplant models are described. Guidelines for therapeutic monitoring of the drug are proposed. It is hoped that such preclinical work in animals will facilitate establishment of monitoring protocols for the drug in clinical trials.
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页码：478 / 482
页数：5
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