CLARITHROMYCIN VERSUS CEFACLOR FOR THE TREATMENT OF MILD-TO-MODERATE ACUTE BACTERIAL BRONCHITIS

被引:13
作者
WETTENGEL, R [1 ]
VETTER, N [1 ]
WAARDENBURG, FA [1 ]
机构
[1] PULM ZENTRUM STADT WIEN,VIENNA,AUSTRIA
关键词
D O I
10.1093/jac/31.6.963
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Four hundred and eight outpatients with the clinical signs and symptoms of mild-tomoderate acute bronchitis of bacterial aetiology were enrolled in a multicentre, double-blind, randomized clinical trial comparing the efficacy and safety of clarithromycin and cefaclor, both administered orally. Two hundred and seven patients received clarithromycin 250 mg bd and 201 patients received cefaclor 500 mg tds for a maximum of seven days. Clinical and bacteriological evaluations were performed before treatment was initiated, during the course of treatment, and within 72 h of completing therapy; all adverse events were recorded. Two hundred and three patients in the clarithromycin group and 195 in the cefaclor group were evaluable for clinical response and 129 and 124 patients in the clarithromycin and cefaclor groups, respectively, were evaluable for bacteriological response. The clinical response rates three to five days after starting treatment and at the post-treatment assessment were 97% (193/199) and 99· (202/203), respectively, for the clarithromycin group and 97·4% (187/192) and 97·9% (191/195), respectively, for the cefaclor group. The bacteriological cure rates were 94·6% (122/129) for the clarithromycin group and 90·3% (112/124) for the cefaclor group. None of the differences between the groups was statistically significant. Adverse events, which were generally mild and predominantly related to the gastrointestinal tract, were reported by 5·8% of clarithro mycin-treated patients and 10·4% of cefaclor-treated patients. Adverse reactions caused one patient in the clarithromycin group and three in the cefaclor group to discontinue treatment prematurely. The results of this study indicate that clarithro mycin and cefaclor are comparable with respect to efficacy and safety when used as treatment for patients with mild-to-moderate acute bacterial bronchitis. © 1993 The British Society for Antimicrobial Chemotherapy.
引用
收藏
页码:963 / 972
页数:10
相关论文
共 37 条
[2]   A COMPARATIVE SAFETY AND EFFICACY STUDY OF CLARITHROMYCIN AND ERYTHROMYCIN STEARATE IN COMMUNITY-ACQUIRED PNEUMONIA [J].
ANDERSON, G ;
ESMONDE, TS ;
COLES, S ;
MACKLIN, J ;
CARNEGIE, C .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1991, 27 :117-124
[3]   AN INVITRO EVALUATION OF THE CELLULAR UPTAKE AND INTRAPHAGOCYTIC BIOACTIVITY OF CLARITHROMYCIN (A-56268, TE-031), A NEW MACROLIDE ANTIMICROBIAL AGENT [J].
ANDERSON, R ;
JOONE, G ;
VANRENSBURG, CEJ .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 22 (06) :923-933
[6]   COMPARATIVE INVITRO ACTIVITY OF A-56268 (TE-031) AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA AND CHLAMYDIA-TRACHOMATIS [J].
BENSON, C ;
SEGRETI, J ;
KESSLER, H ;
HINES, D ;
GOODMAN, L ;
KAPLAN, R ;
TRENHOLME, G .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1987, 6 (02) :173-178
[7]   DIRECT AND INDIRECT PATHOGENICITY OF BRANHAMELLA-CATARRHALIS [J].
BROOK, I .
DRUGS, 1986, 31 :97-102
[8]  
BROWN RB, 1988, CLIN THER, V11, P54
[9]   PHARMACOKINETICS OF CLARITHROMYCIN, A NEW MACROLIDE, AFTER SINGLE ASCENDING ORAL DOSES [J].
CHU, SY ;
SENNELLO, LT ;
BUNNELL, ST ;
VARGA, LL ;
WILSON, DS ;
SONDERS, RC .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (11) :2447-2453
[10]   EPIDEMIOLOGIC AND BACTERIOLOGICAL FINDINGS ON BRANHAMELLA-CATARRHALIS RESPIRATORY-INFECTIONS IN THE NETHERLANDS [J].
DAVIES, BI ;
MAESEN, FPV .
DRUGS, 1986, 31 :28-33