RAPID DNA FRAGMENTATION FROM HYPOXIA ALONG THE THICK ASCENDING LIMB OF RAT KIDNEYS

被引：116

作者：

BEERI, R

SYMON, Z

BREZIS, M

BENSASSON, SA

BAEHR, PH

ROSEN, S

ZAGER, RA

机构：

[1] HADASSAH UNIV HOSP,DEPT MED,IL-91240 JERUSALEM,ISRAEL

[2] HEBREW UNIV JERUSALEM,JERUSALEM,ISRAEL

[3] BETH ISRAEL HOSP,DEPT PATHOL,BOSTON,MA 02215

[4] HARVARD UNIV,SCH MED,BOSTON,MA

[5] WASHINGTON UNIV,FRED HUTCHINSON CANC RES CTR,SEATTLE,WA

[6] WASHINGTON UNIV,DEPT MED,SEATTLE,WA

来源：

KIDNEY INTERNATIONAL | 1995年 / 47卷 / 06期

关键词：

D O I：

10.1038/ki.1995.249

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Extensive DNA fragmentation, a marker for programmed cell death, was selectively and rapidly induced by hypoxia in the thick ascending limbs of rat kidneys. In isolated perfused kidneys, DNA breaks were present in medullary tubules as early as after 10 minutes of local hypoxia and were prevented by reduction of metabolic work. In a model of radiocontrast-induced acute renal failure, DNA breaks were detected selectively along thick ascending limbs as early as 15 minutes following insult, preceding overt morphological damage. Hypoxia induces rapid DNA fragmentation along thick ascending limbs, where programmed cell death could pray an important role in nephron injury and kidney failure.

引用

页码：1806 / 1810

页数：5

共 38 条

[1] NITRIC-OXIDE AND PROSTANOIDS PROTECT THE RENAL OUTER MEDULLA FROM RADIOCONTRAST TOXICITY IN THE RAT [J].